Abnormal Vasomotor Function of Porcine Coronary Arteries Distal to Sirolimus-Eluting Stents
نویسندگان
چکیده
منابع مشابه
Abnormal vasomotor function of porcine coronary arteries distal to sirolimus-eluting stents.
OBJECTIVES This study sought to determine vasomotor functional responses of conduit coronary artery distal to bare-metal stents (BMS), polymer-only stents (POLY), and sirolimus-eluting stents (SES) in a clinically relevant animal model. BACKGROUND Drug-eluting stents (DES) reduce in-stent restenosis, and also affect neointima formation and vascular remodeling in downstream coronary segments. ...
متن کاملComparison of inflammatory response after implantation of sirolimus- and paclitaxel-eluting stents in porcine coronary arteries.
BACKGROUND Although both sirolimus (CYPHER) and paclitaxel (TAXUS) drug-eluting stents have demonstrated efficacy and safety in clinical trials, human autopsy data have raised concerns about long-term healing and the potential for local inflammatory reactions. METHODS AND RESULTS Overlapping stents (CYPHER drug-eluting stents, Bx SONIC bare metal stents, TAXUS drug-eluting stents, and Liberté...
متن کاملSirolimus-eluting coronary stents: a review
The sirolimus-eluting coronary stent received CE Mark approval in Europe in April 2002. In the US, FDA approval followed in April 2003. Since the preliminary results from the First-in-Man feasibility study were presented, several randomized, controlled trials have documented the profound antiproliferative effects of sirolimus, a macrolide antibiotic and potent cytostatic inhibitor of smooth mus...
متن کاملSirolimus-eluting vs uncoated stents for prevention of restenosis in small coronary arteries: a randomized trial.
CONTEXT Percutaneous coronary revascularization of small vessels is associated with a high restenosis rate. Sirolimus-eluting stents reduce restenosis in simple and previously untreated lesions of large coronary arteries, but their outcomes in small vessels have not been adequately investigated. OBJECTIVE To determine whether sirolimus-eluting stents are associated with a reduced 8-month rate...
متن کاملLong-term effects of polymer-based, slow-release, sirolimus-eluting stents in a porcine coronary model.
BACKGROUND Stent-based delivery of sirolimus (SRL) has shown reduction in neointimal hyperplasia and restenosis. The purpose of this study was to evaluate the chronic vascular response and the expression of cell cycle regulators after SRL-eluting stent implantation in a porcine coronary model. METHODS Forty-nine pigs underwent placement of 109 oversized stents (control, n=54, SRL (140 microg/...
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ژورنال
عنوان ژورنال: JACC: Cardiovascular Interventions
سال: 2008
ISSN: 1936-8798
DOI: 10.1016/j.jcin.2008.01.009